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Apply These Secret WAYS TO Improve Pregnancy Loss And Chromosome Testing For Miscarriages

Although most couples are blissfully unaware of the statistics surrounding miscarriage, pregnancy loss is really quite common, with 10-25% of recognized pregnancies ending in miscarriage. In case you have suffered a pregnancy loss or are in the process of experiencing a miscarriage, you could be wondering what caused the loss and worry about whether it will happen again. This article aims to answer the next questions:

What causes miscarriage?
How common is pregnancy loss?
What sort of genetic testing can be acquired for miscarriage tissue?
How can chromosome testing help?
Causes of Miscarriage

There are many different explanations why miscarriage occurs, but the most typical cause for first trimester miscarriage is a chromosome abnormality. Chromosome abnormalities – extra or missing whole chromosomes, also called “aneuploidy” – occur because of a mis-division of the chromosomes in the egg or sperm involved with a conception. Typically, humans have 46 chromosomes which come in 23 pairs (22 pairs numbered from 1 to 22 and then the sex chromosomes, X and Y). For a baby to develop normally it is important that it have exactly the right amount of chromosome material; missing or extra material during conception or in an embryo or fetus can cause a woman to either not get pregnant, miscarry, or have a baby with a chromosome syndrome such as for example Down syndrome.

Over 50% of all first trimester miscarriages are due to chromosome abnormalities. This number may be closer to 75% or higher for women aged 35 years and over who’ve experienced recurrent pregnancy loss. Overall, the rate of chromosome abnormalities and the rate of miscarriage both increase with maternal age, with a steep increase in women older than 35.

Pregnancy Loss – How Common is it?

Miscarriage is far more common than a lot of people think. Up to one in every four recognized pregnancies is lost in first trimester miscarriage. The opportunity of having a miscarriage also increases as a mother ages.

Nearly all women who experience a miscarriage continue to get a healthy pregnancy rather than miscarry again. However, some women seem to be more susceptible to miscarriage than others. pregnancy loss About five percent of fertile couples will experience several miscarriages.

Of note, the rate of miscarriage is apparently increasing. One reason for this may be awareness – more women know they’re having a miscarriage because home pregnancy tests have improved early pregnancy detection rates over the past decade, whereas previously the miscarriage would have were just an unusual period. Another reason may be that more women are conceiving at older ages.

Types of Genetic Testing Ideal for Miscarriages

Genetic testing actually identifies many types of testing that can be done on the DNA in a cell. For miscarriage tissue, also known as products of conception (POC), probably the most useful type of test to execute is a chromosome analysis. A chromosome analysis (also called chromosome testing) can examine all 23 pairs of chromosomes for the current presence of extra or missing chromosome material (aneuploidy). Because so many miscarriages are caused by aneuploidy, chromosome analysis on the miscarriage tissue can often identify the reason for the pregnancy loss.

The most common method of chromosome analysis is named karyotyping. Newer methods include advanced technologies such as microarrays.

Karyotyping analyzes all 23 pairs of chromosome but requires cells from the miscarriage tissue to first be grown in the laboratory, an activity called “cell culture”. For this reason requirement, tissue that is passed at home is frequently unable to be tested with this particular method. About 20% or more of miscarriage samples neglect to grow and thus no email address details are available. Additionally, karyotyping is unable to tell the difference between cells from the mother (maternal cells) and cells from the fetus. In case a normal female result is available, it may be the correct result for the fetus or it can be maternal cell contamination (MCC) in which the result actually comes from testing the mother’s cells within the pregnancy tissue rather than the fetal cells. MCC appears to occur in about 30% or more of the samples tested by traditional karyotype. Results from karyotyping usually have a few weeks to months to come back from the laboratory.

Microarray testing is really a new type of genetic testing done on miscarriage samples; the two most common types of microarray testing are array CGH (comparative genomic hybridization) and chromosome SNP (single-nucleotide polymorphism) microarray. Microarray testing is also in a position to test all 23 pairs of chromosomes for aneuploidy, but does not require cell culture. Therefore, you are more likely to receive results and the results are usually returned faster when microarray testing can be used. Additionally, some laboratories are collecting an example of the mother’s blood simultaneously the miscarriage tissue is sent to enable immediate detection of maternal cell contamination (MCC).

Chromosome Testing – How do it help?

If a chromosome abnormality is identified, the sort of abnormality found can be assessed to help answer the question: “Will this happen to me again?”. Usually, chromosome abnormalities in an embryo or fetus aren’t inherited and have a minimal chance to occur in future pregnancies. Sometimes, a particular chromosome finding in a miscarriage alerts your physician to do further studies to investigate the possibility of an underlying genetic or chromosome problem in your family that predisposes you to have miscarriages.

Furthermore, if a chromosome abnormality is identified it could prevent the need for other, sometimes quite costly, studies your physician might consider to investigate the reason for the miscarriage.

Lastly, knowing the reason for a pregnancy loss might help a couple start the emotional healing process, moving at night question of “Why did this happen to me?”.

Chromosome testing can be especially very important to patients with repeated miscarriages, as it could either give clues to an underlying chromosomal cause for the miscarriages or eliminate chromosome errors as the reason for the miscarriages and invite their doctor to pursue other styles of testing. For couples with multiple miscarriages determined to have a chromosomal cause, in vitro fertilization (IVF) with preimplantation genetic diagnosis (PGD) testing might be able to help increase their chances of having a successful healthy pregnancy.